Bone morphogenetic proteins (BMPs) make up the largest subfamily within the transforming growth factor superfamily (Massague, 1998). Bone morphogenetic protein signals through a heteromeric complex of type I and type II transmembrane serine kinase receptors. To date, three distinct type I receptors, such as activin receptor like kinase 2 (ALK2), BMP receptor type IA (BMPR IA and BMP receptor type IB (BMPR IB have been identified.
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